Abstract. CARDONA ALVAREZ, José; VARGAS VILORIA, Marlene and PERDOMO AYOLA, Sandra. Equine Skin Pythiosis: a review. Ces. Med. Vet. Zootec. Pythiosis cutánea en equinos tratados con acetonida de triamcinolona. Parte 1. .. ao estudo da pitiose cutânea equina em equídeos do pantanal norte, Brasil. Tratamento contra Pitiose em Equinos - Duration: 3 minutes, 53 seconds. views; 5 years ago. Play next; Play now.
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The present report concerns a year-old mixed breed gelding presenting with self-mutilation of a tumoral mass located at the left flank. The owners reported that the pitiose equina had initially presented a small wound that had evolved to a cm in diameter mass pitiose equina 4 weeks.
Acta Scientiae Veterinariae
Tissue samples were collected, processed and stained by the Gomori's methenamine silver GMS method. The histopathological analysis revealed Pythium insidiosum pitiose equina in a granulomatous tissue, especially located at peripheral region, where kunkers were present.
Surgical excision of the mass followed by cauterization was indicated as pitiose equina treatment, and due to financial reasons, the owners elected only the topical antifungal therapy to control the fungus infection after surgery.
Flunixin meglumine was also administrated for five days aiming the control of pain and inflammation. The wound was cleaned with povidone-iodine solution and rinsed with a solution containing, 50 mg, pitiose equina amphotericin B in 10 mL of sterile water and 10 mL of DMSO.
Semina: Ciências Agrárias
This procedure was carried Out twice a day. The wound healed fast due to an excellent centripetal epithelialization.
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The owner reported by telephone the complete healing and hair growth 10 days pitiose equina discharge. Despite the atypical location of the tumoral lesion described at the present report, the history and clinical manifestations, especially the intense pruritus, showed similarity with other characteristic reports of equine cutaneous pythiosis.
On the other hand, surgical intervention as part of the treatment for pythiosis, requires removal of the entire affected area, with a safety margin to avoid relapses, however, this is hampered by compromised anatomical structures, mainly in the limbs After contact of P.
The high number of eosinophils de-granulates around the hyphae of P. It is suggested that the SH phenomenon and the exo-Ags secretion are evolutionary strategies developed by P. The entire spectrum of molecular albs explains both pleiotropy and anti-inflammatory and immuno-modulatory force.
That is why, by blocking the synthesis of the cytokine IL-5 and granulocyte-macrophage colony-stimulating factor GM-CSFthe programmed death of these cells apoptosis is triggered, which decreases the half-life of Eosinophils.
Once this cytokine is responsible for eosinophilopoiesis, the function of mature eosinophils increases, as well as de-granulation, adhesion and cytotoxicity, thus prolonging the survival of that cell 23 AT decreases the half-life of the eosinophil by blocking the synthesis of IL-5 and granulocyte-macrophage colony stimulating factor GM-CSFtriggering the apoptosis of these cells, and thus Pythium is exposed to neutrophils And macrophages, which completely eliminate the hyphae in the tissue, stimulating the physiological repair of the wound.
Additionally glucocorticoids prolong the survival of the neutrophils and decrease the apoptosis of these cells In the healing process, many cell types are involved whose interrelationships are regulated by the cytokines, the extracellular matrix ECM and the metalloproteinases MMPs of the extracellular matrix.
In pitiose equina chronic wound as the antigenic stimulus disappears, skin healing is activated allowing the reconstruction of the stratified epithelium the epidermisthe epidermal dermal pitiose equina and the dermis, as well as its vascularization After treatment with AT in the GT, the reconstitution of the tissue begins, with the accumulation of fibroblasts in the center of the wound, and initiates the synthesis of collagen and a provisional extracellular matrix.
Fibroblasts undergo a series of phenotypic changes, initially adopting a migratory phenotype, then a pro-fibrotic phenotype as they produce collagen I, III and Pitiose equina and subsequently, adopting the myo-fibroblast phenotype, rich in actin microfilaments in the cytoplasmic side of the membrane to establish cell-cell adherent junctions.
These cells produce the necessary new MEC for the supporting cells and blood vessels, provide nutrients and oxygen necessary for cell growth and proliferation Simultaneously, fibroblasts and endothelial cells begin to migrate on the provisional matrix in the wound space with the help of MMPs extracellular matrix metalloproteinaseswhich are regulated by keratinocytes and macrophages at the wound border.
Scientific Electronic Archives
The degradation of the ECM components by MMP is necessary to remove and rearrange provisional matrices and allow migration, providing formation of new blood vessels in the wound bed.
Collagen is a fundamental component in the pitiose equina repair process, and it is synthesized from fibroblasts and present in abundance in the pitiose equina phase and remodeling of the wound.
The most expressive types of collagen in the healing process are types I and III.